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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
30.61
Human Site:
S505
Identified Species:
48.1
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
S505
S
P
E
R
R
C
R
S
V
E
L
D
L
N
Q
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
S505
S
P
E
R
R
C
R
S
V
E
L
D
L
N
Q
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
S505
S
P
E
R
R
C
R
S
V
E
L
D
L
N
Q
Dog
Lupus familis
XP_538730
651
74149
S505
S
P
E
R
R
C
R
S
V
E
L
D
L
N
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
S497
S
P
E
R
R
C
R
S
M
D
V
D
L
N
Q
Rat
Rattus norvegicus
P54645
559
63955
K429
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
S509
S
P
E
R
R
C
H
S
V
E
L
A
L
N
Q
Chicken
Gallus gallus
NP_001026680
657
74208
S511
L
P
E
K
R
C
H
S
V
D
L
D
L
N
R
Frog
Xenopus laevis
NP_001081569
651
74289
S505
S
P
E
R
R
C
R
S
V
E
L
D
L
N
Q
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
R762
P
P
P
T
S
L
P
R
M
A
L
A
N
Q
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
Q476
N
E
N
I
D
P
D
Q
P
N
V
L
S
G
K
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
A558
S
I
G
S
A
H
S
A
N
N
A
D
G
R
T
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
R825
S
M
E
D
S
L
D
R
V
M
M
E
D
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
A310
E
K
R
E
E
Q
P
A
A
I
N
A
F
E
I
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
V497
A
S
K
I
S
P
L
V
T
K
K
S
K
T
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
100
100
N.A.
80
6.6
N.A.
86.6
66.6
100
20
N.A.
N.A.
0
13.3
20
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
86.6
86.6
100
26.6
N.A.
N.A.
20
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
0
0
7
7
0
14
7
7
7
20
0
0
0
% A
% Cys:
0
0
0
7
0
54
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
7
0
14
0
0
14
7
54
7
0
7
% D
% Glu:
7
14
60
7
7
0
0
0
0
40
0
7
7
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
7
0
0
0
0
0
0
0
0
0
7
14
0
% G
% His:
0
0
0
0
0
7
14
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
14
0
0
7
0
0
7
0
0
0
0
7
% I
% Lys:
0
7
7
7
0
0
0
7
0
7
7
0
7
0
14
% K
% Leu:
7
0
0
0
0
14
7
0
0
7
54
7
54
0
0
% L
% Met:
0
7
0
0
0
0
0
0
14
7
7
0
0
0
0
% M
% Asn:
7
0
7
0
0
0
0
0
7
14
7
0
7
54
0
% N
% Pro:
7
60
7
0
0
14
14
0
7
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
0
7
7
0
0
0
0
7
54
% Q
% Arg:
0
0
7
47
60
0
40
14
0
0
0
0
0
7
14
% R
% Ser:
60
7
0
7
20
0
7
54
0
0
0
7
7
0
0
% S
% Thr:
0
0
0
7
0
0
0
0
7
0
0
0
0
7
7
% T
% Val:
0
0
7
0
0
0
0
7
54
0
14
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _